摘要
目的:应用超声多普勒成像技术探讨血流剪切率在兔动脉粥样硬化斑块形成中的作用。方法:29只兔子通过动脉内膜损伤术加高脂饮食来形成腹主动脉粥样硬化斑块。然后测定高脂饮食前、动脉内膜损伤术后半个月、1个月、2个月、3个月、4个月时内中膜厚度(IMT)及其校正的声学密度值(AIIc%)、收缩期峰值流速(Vs)、收缩期狭窄处内径(Ds)等指标,并计算血流剪切率(SRs)。结果:IMT逐渐增厚;术后SRs经历一个先低后高再低过程,术后各时间点SRs值与高脂饮食前比有差异(P<0.05)。结论:IMT、AIIc%与动脉粥样硬化斑块厚度高度相关;早期血流剪切力减低是动脉粥样硬化斑块形成的重要危险因素,而后期增大则可引起斑块不稳定。
Abstract
Objective: To investigate the roles of fluid shear rate(SRs) on atherosclerotic plaques in model rabbits through Doppler ultrasound imaging technique. Methods: The atherosclerotic plaques were made in 29 rabbits by undergoing balloon-induced abdominal aorta wall injury and then fed on a diet of high cholesterol. The parameters such as: intima-medial thickness(IMT), average image intensity correction(AIIc%), systolic velocity(Vs), systolic diameter of lumen(Ds) and so on were measured with ultrasound imaging before a diet of high cholesterol and half month, one month, two months, three months and four months after abdominal aorta wall injured. Then SRs was calculated as well. Results: IMT became thicker and thicker. After abdominal aorta wall injured, the SRs first became low and then high, finally became low. The values of SRs after abdominal aorta wall injured were different with that before a diet of high cholesterol(P<0.05). Conclusions: IMT, AIIc% were significantly related to the thickness of atherosclerotic plaques. Lower SRs was one of the factors important in the shaping of atheros-clerotic plaques, but higher SRs may make atherosclerotic plaques unstable.
关键词
主动脉 /
腹 /
动脉硬化 /
超声检查 /
多普勒 /
彩色
Key words
aorta /
abdominal /
arteriosclerosis /
ultrasonography /
Doppler /
color
陈祥华;冯向飞;汤政德;盛 净;陈朝婷.
兔腹主动脉粥样硬化斑块与血流剪切率关系研究[J]. 中国临床医学影像杂志. 2006, 17(5): 260-263
CHEN Xiang-hua;FENG Xiang-fei;TANG Zheng-de;SHENG Jing;CHEN Chao-ting.
Study of relationship between fluid shear rate and atherosclerotic plaque in abdominal aorta in model rabbits[J]. Journal of China Clinic Medical Imaging. 2006, 17(5): 260-263
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