正常人视觉刺激下心算任务的功能磁共振成像研究

肖慧; 陈自谦; 钱根年; 倪萍; 陈锦华; 王锦良; 杨熙章

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中国临床医学影像杂志 ›› 2007, Vol. 18 ›› Issue (12) : 837-840.

论著

正常人视觉刺激下心算任务的功能磁共振成像研究

肖慧1，陈自谦2，钱根年2，倪萍2，陈锦华2，王锦良2，杨熙章2

作者信息 +

Study of mental calculations under visual stimulation with functional MRI

XIAO Hui1, CHEN Zi-qian2, QIAN Gen-nian2, NI Ping2, CHEN Jin-hua2, WANG Jin-liang2, YANG Xi-zhang2

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摘要

目的：采用功能磁共振成像（fMRI）技术对正常人视觉刺激下简单心算任务进行研究，探讨不同计算任务类型相关脑功能区的定位及作用机制，进一步理解人脑高级思维模式。资料与方法：对12名右利手志愿者（男6名，女6名）进行简单加法计算、简单减法计算和退位减法计算任务的fMRI研究。应用组块设计模式，采用GE 1.5T磁共振扫描仪，对所有志愿者行T1WI和fMRI。采用AFNI软件进行数据分析和脑功能区定位，同时记录被试的计算正确率和反应时间。结果：12名被试中共获取10人的行为学数据。3种心算任务模式随计算难度的增加，平均反应时间延长，计算正确率下降。男女间比较复杂减法任务计算正确率存在差异，女性低于男性（P<0.05）。3种计算任务存在共同激活脑区，额叶为减法任务主要相关脑区。随任务难度加深，脑总体激活体积增大。结论：fMRI可以简单便捷地定位心算相关脑功能区，心算为多个脑功能区协同工作的复杂过程。

Abstract

Objective: To study mental calculations under visual stimulation of normal adult with functional MRI(fMRI) and investigate the roles of local areas for digital calculations． Materials and Methods: Twelve right-handed healthy subjects received exam include simple calculation and complex calculation experiment． Following block design, T1WI and GRE-EPI fMRI were performed with a 1.5T whole body MRI scanner． AFNI was used to process data and localize functional areas． The reaction time and correct ratio were analyzed with the statistical software Exce1． Results: Ten of 12 adults’ data were achieved. The reaction time were longer and correct ratio were decreased along with the task’s difficulty. The correct ratio of complex subtraction was different apparently between male and female. The male were superior to the female(P<0.05). Prefrontal cortex was the main area in the complex calculation． Compared with simple calculation, extent and magnitude of functional areas were increased obviously in complex calculation． Conclusion: fMRI can easily and readily detect brain functional areas related to mental calculations． Multiple functional areas are related to digital calculations and these areas may work together as a whole in processing arithmetic problems．

导出引用

肖慧;陈自谦;钱根年;倪萍;陈锦华;王锦良;杨熙章. 正常人视觉刺激下心算任务的功能磁共振成像研究[J]. 中国临床医学影像杂志. 2007, 18(12): 837-840

XIAO Hui;CHEN Zi-qian;QIAN Gen-nian;NI Ping;CHEN Jin-hua;WANG Jin-liang;YANG Xi-zhang. Study of mental calculations under visual stimulation with functional MRI[J]. Journal of China Clinic Medical Imaging. 2007, 18(12): 837-840

中图分类号： Ｒ338.2 Ｒ445.2