摘要
目的：评价乳腺癌灶的大小，乳腺组织密度、年龄、绝经状态对18F-脱氧葡萄糖（FDG）PET/CT标准摄取值的影响。方法：对27例临床疑单侧原发性乳腺癌患者（13例绝经前期和14例绝经后期）行18F-FDG PET/CT显像。应用ROI技术行半定量方法测得癌灶的SUVmax，并应用图像处理软件镜像技术勾画对侧正常组织的SUVmax。与乳腺病变的大小、组织密度、患者年龄、绝经状态行相关性分析。所有患者均行手术治疗。结果：27例患者共32个病灶。病理证实，乳腺癌25个，良性病变7个。乳腺癌病灶SUVmax为5.08±3.55，良性病变SUVmax为1.17±0.31，对侧正常腺体组织SUVmax为0.76±0.52。乳腺病灶SUVmax与病灶的最长径呈显著性正相关（r=0.546，P＜0.05)。病灶SUVmax与患者年龄呈显著性负相关（r=-0.45，P＜0.05)。正常乳腺组织的SUVmax与患者年龄无显著性相关（P＞0.05）。病灶与正常乳腺组织SUVmax与CT值、绝经状态无显著性相关（P＞0.05）。结论：乳腺病变患者年龄及病灶大小影响18F-FDG SUVmax，在疾病的良恶性鉴别时应引起关注。当病变组织密度发生较大变化时，18F-FDG PET可对乳腺肿物的良、恶性鉴别提供较可靠依据。
Abstract
Objective: To evaluate the effect of age, size of foci, the CT value of foci, serum glucose level, menopausal status on the 18F-FDG uptake in normal breast tissue and breast cancer by quantitative standardized uptake values(SUV). Methods: Twenty-seven patients(premenopausal 13; postmenopausal 14) highly suspected of breast cancer underwent FDG PET/CT imaging. The semi-quantitative analysis methods of FDG uptake were used. We analyzed for contralateral normal breast tissue. To analyze the correlations between the SUVmax and age, size, the CT value, menopausal status. Results: Thirty-two breast lesions were found in operation and all were confirmed histologically. Of the 32 lesions, 25 were malignant and 7 benign. SUVmax of malignant lesion, benign lesion and contralateral normal breast tissue were 5.08±3.55, 1.17±0.31, 0.76±0.52, respectively. The SUV of malignant lesion was significantly higher than those of contralateral normal breast and benign lesion(all P<0.01). There was no significant difference between benign lesion and normal breast in SUV(P>0.05). Significant correlation of breast disease was found between the SUVmax and age, size. There was no correlations between SUVmax and size of foci, the CT value or menopausal status. There were no significant correlations of normal breast tissue between them. Conclusions: The age and size of breast disease have significant effect on SUV of 18F-FDG uptake. 18F-FDG PET is a reliable method in differentiating malignant and benign lesions of the breast.
关键词
乳腺肿瘤 /
正电子发射断层显像术
Key words
breast neoplasms /
positron-emission tomography
李雪娜;尹雅芙;李亚明.
18F-FDG PET/CT乳腺癌病灶标准摄取值与其影响因素的相关性研究[J]. 中国临床医学影像杂志. 2007, 18(12): 844-845
LI Xue-na;YIN Ya-fu;LI Ya-ming.
Relationship between 18F-FDG uptake and the factors influence the standardized uptake value of breast cancer[J]. Journal of China Clinic Medical Imaging. 2007, 18(12): 844-845
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