应变及应变率成像评价急性缺血再灌注局部心肌收缩功能的实验研究

林萍; 任卫东; 刘长宏; 夏稻子; 武俊; 王月爱

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中国临床医学影像杂志 ›› 2007, Vol. 18 ›› Issue (4) : 240-242.

论著

应变及应变率成像评价急性缺血再灌注局部心肌收缩功能的实验研究

林萍1，任卫东2，刘长宏1，夏稻子1，武俊1，王月爱1

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Assessment of left ventricular segmental function during acute ischemia reperfusion by strain and strain rate imaging

LIN Ping1, REN Wei-dong2, LIU Chang-hong1, XIA Dao-zi1, WU Jun1, WANG Yue-ai1

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摘要

目的：本实验旨在探讨用应变及应变率成像评价缺血再灌注心肌局部功能的可行性。方法：14只健康杂种犬麻醉后开胸，于第一对角支起点以下套扎冠状动脉左前降支，结扎后30min，再灌注120min，建立缺血再灌注模型。分别于结扎前、结扎后30min，再灌注后30min、60min、120min，采集连续3个心动周期组织速度图，用应变及应变率软件分析左室前壁各节段应变及应变率曲线。Simpson’s双平面法测量左室射血分数（LVEF），舒张末（EDV）及收缩末容积（ESV）。结果：14只犬中12只成功建立缺血再灌注模型。结扎后30min，左室前壁缺血节段收缩期峰值应变（εpeak），应变率（SRpeak）明显降低（P<0.05），再灌注30min后缺血节段εpeak及SRpeak进一步减低，再灌注60min及120min后εpeak 及SRpeak有所恢复，但仍未达到结扎前水平。LVEF，EDV，ESV于冠脉结扎前后差异无显著意义（P>0.05）。结论：应变及应变率能定量评价局部心肌运动异常。可以做为评价局部心肌缺血再灌注心肌功能的指标。

Abstract

Objective: We aimed to investigate the feasibility of quantitative evaluation for regional left ventricular contractile function during acute ischemia reperfusion(AIR) using strain and strain rate imaging echocardiography. Methods: Fourteen anesthesia opened-chest dogs were scanned before, ligation, subsequently reperfused for 30min, 60min and 120min. Three complete cardiac cycles were stored in cineloop format of tissue velocity imaging. Off-line left ventricular regional strain and strain rate along long axis using digital workstation were obtained and analyzed the features of strain rate. Left ejection fraction(LVEF), end-diastolic volume(EDV) and end-systolic volume(ESV) were obtained by Simpson biplane method. Results: AIR modes of 12 dogs were successfully established from 14 dogs. The peak systolic strain(εpeak) and the peak systolic strain rate(SRpeak) in ischemic segment was decreased at 30min after left anterior descending coronary artery(LAD) ligation(P<0.05). εpeak and SRpeak was decreased seriously during reperfusion 30min. εpeak and SRpeak increased slightly after reperfusion 60min and 120min, but still decreased than before ligation. There is no significant difference between before and after LAD ligation at LVEF, EDV, ESV(P>0.05). Conclusions: Regional wall motion abnormalities can be evaluated quantitatively and synchronously with high sensitivity by strain and strain rate which has the potential value in early diagnosis of regional myocardial ischemia and reperfusion.

导出引用

林萍;任卫东;刘长宏;夏稻子;武俊;王月爱. 应变及应变率成像评价急性缺血再灌注局部心肌收缩功能的实验研究[J]. 中国临床医学影像杂志. 2007, 18(4): 240-242

LIN Ping;REN Wei-dong;LIU Chang-hong;XIA Dao-zi;WU Jun;WANG Yue-ai. Assessment of left ventricular segmental function during acute ischemia reperfusion by strain and strain rate imaging[J]. Journal of China Clinic Medical Imaging. 2007, 18(4): 240-242

中图分类号： Ｒ541 Ｒ445.1