摘要
目的：分析肝癌FDG摄取与疾病预后的关系。方法：获得随诊的肝脏恶性肿瘤28例，18F-FDG PET显像后，在肝内病灶的部位设感兴趣区（ROI），计算出该部位的标准摄取值（SUV），分为两种类型：A型：FDG摄取高于周围正常组织，共20例，其中肝细胞肝癌（HCC）19例，胃类癌肝转移1例。B型：FDG摄取与周围正常组织相近或低于周围正常组织，共8例，其中HCC 6例，HCC肝内多发转移1例，十二指肠类癌肝转移1例。结果：随诊18~84个月（m），A型存活期为20.2±16.8（2~72）m；B型存活期为44.8±19.7（32~84）m，其中肝转移性类癌1例和HCC肝内多发转移1例均仍存活，生存期分别为36m和84m。统计学结果示B型组生存期明显长于A型组。结论：HCC的多样性显像给诊断增加了难度，但同时，摄取等级的不同又与疾病的转归有关，无论是HCC还是转移性肝癌，FDG摄取较低提示疾病预后较好。
Abstract
Objective: To evaluate the various levels of FDG uptake for patient with malignant liver tumor. Methods: FDG PET were performed for 28 patients with malignant liver tumor. Region of interest(ROI) was placed over the tumor regions and the standardized uptake value(SUV) was calculated. Then the tumors were divided into the following two types: FDG uptake increased(type A) was seen in 20 patients, including 19 HCC and one liver metastasis of gastrointestinal carcinoid tumour. FDG uptake similar to the surrounding nontumor liver tissue(type B) was seen in 8 patients, including 6 HCC and one liver metastasis of gastrointestinal carcinoid tumour and one liver metastasis of HCC. Result: After following up to 18~84 months, the cumulative survival rate was found to be singnificant higher in group B than in group A(44.8±19.7 months vs 20.2±16.8 months.)(P<0.05). The survival time was significant different between patient of liver metastasis from gastrointestinal carcinoid tumor according to the uptake degrees. Conclusions: HCC is heterogenous in terms of its glucose metabolism. The degree of FDG uptake is useful to predict the outcome of malignant liver tumors.
关键词
肝肿瘤 /
氟脱氧葡萄糖F18 /
正电子发射断层显像术
Key words
liver neoplasms /
positron-emission tomograpy /
Fluorodeoxyglucose F18
徐白萱;尹大一;陈英茂;姚树林;杨自更;田嘉禾.
肝癌18F-FDG PET摄取与预后关系的分析[J]. 中国临床医学影像杂志. 2007, 18(6): 399-400
XU Bai-xuan;YIN Da-yi;CHEN Ying-mao;YAO Shu-lin;YANG Zi-geng;TIAN Jian-he.
Analysis of 18F-FDG PET uptake and prognosis of patients with malignant liver tumor[J]. Journal of China Clinic Medical Imaging. 2007, 18(6): 399-400
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