采用离子液体作为相转移催化剂一步法合成18F-FDG方法学研究

辛军; 李宏利; 郭启勇; 赵周社; 周佟; 李云涛

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中国临床医学影像杂志 ›› 2007, Vol. 18 ›› Issue (6) : 428-430.

论著

采用离子液体作为相转移催化剂一步法合成18F-FDG方法学研究

辛军1，李宏利2，郭启勇1，赵周社2，周佟1，李云涛1

作者信息 +

Synthetic methods research of 18F-FDG as phase-transfer calalyst by ionic liquid with one step methodology

XIN Jun1, LI Hong-li2, GUO Qi-yong1, ZHAO Zhou-she2, ZHOU Tong1, LI Yun-tao1

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摘要

目的：建立以离子液体（ionic liquid, IL）作为相转移催化剂（Phase Transfer Catalyst, PTC）合成18F-FDG方法。材料和方法：采用1,3,4,6-四-氧-乙酰基-2-氧-三氟甲磺酰-D-吡喃甘露糖（TATM）作为前体，在不同K2CO3体积、离子液体积、前体量时18F-FDG合成效率及放射化学纯度。结果：采用25mg　TATM 在0.2ml K2CO3、0.3ml离子液体体积、0.7ml乙腈时获得最高的合成效率（55%）和放射化学纯度（93%）。结论：以TATM作为前体，采用离子液体作为PTC和适合的溶剂能够获得高的18F-FDG合成效率。

Abstract

Objective: To develop the new synthetic 18F-FDG method used ionic liquid(IL) as Phase transfer catalyst(PTC). Material and Method: Study the productivity of 18F-FDG with different volume (K2CO3, IL, acetonitrile). 1,3,4,6-tetra-O-acetyl-2-O-trifluromethanesulfonyl-D-mannopyanose(TATM) 25mg precursor and 1-Butyl-3-methylimidazolium trifluoromethanesulfonate(BMI) as PTC. Results: we got the highest 18F-FDG productivity(55%) and radiochemistry purity(93%) with 0.2ml K2CO3, 0.3ml BMI, 0.7ml acetonitrile and TATM 25mg. Conclusion: we can get the highest 18F-FDG productivity used BMI as PTC with TATM precursor.

导出引用

辛军;李宏利;郭启勇;赵周社;周佟;李云涛. 采用离子液体作为相转移催化剂一步法合成18F-FDG方法学研究[J]. 中国临床医学影像杂志. 2007, 18(6): 428-430

XIN Jun;LI Hong-li;GUO Qi-yong;ZHAO Zhou-she;ZHOU Tong;LI Yun-tao. Synthetic methods research of 18F-FDG as phase-transfer calalyst by ionic liquid with one step methodology[J]. Journal of China Clinic Medical Imaging. 2007, 18(6): 428-430

中图分类号： Ｒ817.4 Ｒ817.9