乳腺癌18F-FDG代谢显像与HIF-1α表达相关性的实验研究

宋武战; 池君; 汪静

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中国临床医学影像杂志 ›› 2007, Vol. 18 ›› Issue (7) : 476-478.

论著

乳腺癌18F-FDG代谢显像与HIF-1α表达相关性的实验研究

宋武战1，池君1，汪静2

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Experimental study of correlation between 18F-FDG metabolic imaging and expression of HIF-1α in breast carcinoma

SONG Wu-zhan1, CHI Jun1, WANG Jing2

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摘要

目的：研究乳腺癌18F-FDG代谢显像以及与乏氧诱导因子-1α（HIF-1α）表达水平的相关性。方法：31例乳腺癌的患者行DHC 18F-FDG代谢显像，利用计算机感兴趣区（ROI）技术计算T/NT值（乳腺癌病灶计数/对侧计数），免疫组织化方法检测肿瘤组织HIF-1α表达水平。结果：31个病灶对18F-FDG的摄取均高于对侧正常乳腺组织，T/NT值为2.98±1.09；18F-FDG摄取程度与肿瘤大小无相关关系（P>0.05）；注射18F-FDG 40分钟后DHC显像浸润性导管癌T/NT值为2.98±O.97，浸润性小叶癌T/NT值为2.96±1.45，两者无显著性差异（P>0.05）；病灶的T/NT值分布为1.68~6.49（中位值2.73），免疫组化结果显示表达HIF-1α的细胞数为25.6%~78.5%（中位数56.3%），两者之间呈直线正相关（P<0.01）。结论：乳腺癌组织对糖代谢显像剂18F-FDG有显著的摄取，摄取值与病理类型及病灶大小无相关性，但与HIF-1α的表达存在正相关。

Abstract

Objective: To study the 18F-FDG metabolic imaging in breast carcinoma and the correlation between 18F-FDG uptake and the expression of HIF-1α. Method: Thirty-one patients with primary breast carcinoma diagnosed by fine needle aspiration underwent 18F-FDG metabolic imaging. Regions of interest(ROI) were drawn on the tumor(T) and contralateral normal breast tissue(NT), T/NT ratios were measured for all scans. The expression of HIF-1α was detected by immunohistochemical method. Results: In all 31 patients, 18F-FDG uptake of tumor tissue was obviously higher than that of normal tissue. The T/NT ratios of 31 tumors was 2.98±1.09, and have no relevance to the tumor size(P>0.05). Forty minutes after injecting 18F-FDG, the T/NT ratios of IDC(infiltrating ductal carcinoma) and ILC(infiltrating lobular carcinoma) were 2.98±0.97 and 2.96±1.45(P>0.05). In all 31 patients T/NT ratios ranged from 1.68 to 6.49(median: 2.73). The percentage of tumor cells expressing HIF-1α was 25.6%~78.5%(median: 56.3%), and a positive correlation was found between them(P<0.01). Conclusions: The tissue of breast carcinoma can uptake 18F-FDG obviously and has no relevance to pathologic type and tumor size, but expresses a positive correlation with HIF-1α.

导出引用

宋武战;池君;汪静. 乳腺癌18F-FDG代谢显像与HIF-1α表达相关性的实验研究[J]. 中国临床医学影像杂志. 2007, 18(7): 476-478

SONG Wu-zhan;CHI Jun;WANG Jing. Experimental study of correlation between 18F-FDG metabolic imaging and expression of HIF-1α in breast carcinoma[J]. Journal of China Clinic Medical Imaging. 2007, 18(7): 476-478

中图分类号： Ｒ737.9 Ｒ817.4