基于体素水平分析青少年脑白质结构的年龄变化

邱明国; 李七渝; 刘光久; 谢兵; 王健

中国临床医学影像杂志 ›› 2009, Vol. 20 ›› Issue (12) : 889-892.

论著

基于体素水平分析青少年脑白质结构的年龄变化

邱明国1，李七渝2，刘光久2，谢兵3，王健3

作者信息 +

Voxel-based analysis of white matter during adolescents and young adults

QIU Ming-guo1, LI Qi-yu2, LIU Guang-jiu2, XIE Bing3, WANG Jian3

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文章历史 +

摘要

目的：应用扩散张量成像并基于体素水平分析健康青少年及年轻成年人脑白质结构的年龄变化。方法：选择3组健康志愿者分别进行扩散张量成像，青少年11~13岁组、16~18岁组及年轻成年人23~25岁组。分别对部分各向异性值（FA）、平均扩散系数（MD）与年龄进行线性相关分析，并进行t检验分析不同年龄组间差异。结果：在青少年期发育阶段内囊、额叶和顶叶以及胼胝体等结构的FA值与年龄呈显著正相关，随年龄显著升高。额叶、顶叶及颞叶周边白质的MD值与年龄呈负相关，随年龄增加MD值显著下降。MD值下降与FA值增加很少重叠，反映脑白质不同的生理发育过程。结论：应用扩散张量成像可以动态观测在青少年阶段脑白质结构的发育成熟过程，既有包含脑白质密度的增加也有白质组织结构的完善，FA与MD值变化反映脑白质不同的生理发育过程。

Abstract

Objective: To evaluate differences in white matter by voxel-based analysis in healthy adolescents and young adults. Materials and Methods: Echo-planar diffusion-tensor magnetic resonance(MR) imaging was performed in 3 groups of healthy subjects aged 11~13 years, 16~18 years and 23~25 years. Linear correlative analysis was performed for fractional anisotropy(FA) and mean diffusivity(MD) with age, as well as an intergroup t-test comparison for FA and MD maps. All tests on FA were performed using an absolute threshold of FA>0.15, and set all MD>0.001 to zero. Results: Significant positive correlation of FA with age was found in the internal capsule, the frontal and parietal white matter, the genu and body of the corpus callosum. Statistically significant negative correlation of the MD with age was found in the peripheral frontal and parietal white matter. The minimal overlap in decreases of the MD and increases of FA may indicate that they mainly reflect different physiologic processes. Conclusion: Diffusion-tensor MR imaging results indicate that white matter maturation assessed at different ages involves increases in both white matter density and organization during adolescents and young adults. The FA and MD may reflect different physiologic processes in healthy adolescents and young adults.

导出引用

邱明国;李七渝;刘光久;谢兵;王健. 基于体素水平分析青少年脑白质结构的年龄变化[J]. 中国临床医学影像杂志. 2009, 20(12): 889-892

QIU Ming-guo;LI Qi-yu;LIU Guang-jiu;XIE Bing;WANG Jian. Voxel-based analysis of white matter during adolescents and young adults[J]. Journal of China Clinic Medical Imaging. 2009, 20(12): 889-892

中图分类号： Ｒ322.81 Ｒ445.2