摘要
目的：探讨双源CT灌注成像参数在胃癌生物学行为评估中的作用和价值。材料和方法：用双源CT对胃癌患者行灌注扫描，获得灌注参数值，再分别根据肿瘤细胞分化程度、胃壁浸润深度和有无淋巴结转移等分成若干组，比较各组患者灌注参数值的差异。结果：BF值、BV值远隔转移组和近期远隔转移组大于无远隔转移组，具有显著性差异，P＜0.05（F=6.555、5.972）。BV值肌层浸润组和浆膜浸润组小于浆膜外组，具有显著性差异，P＜0.05（F=5.460）。Patlak P肌层浸润组小于浆膜外组，具有显著性差异。PBV值与胃癌细胞分化程度呈负相关，BV、BF、Patlak P、PBV与浸润深度呈正相关，BV、BF、Patlak P与远隔转移程度呈正相关，Patlak P与淋巴转移程度呈正相关。结论：双源CT灌注成像参数能够科学的评估胃癌的生物学行为。BF值、BV值能够对是否发生远隔转移和术后近期远隔转移进行评估。BV值、Patlak P值能够对癌组织胃壁浸润深度进行评估。
Abstract
Objective: To discuss the value of dual source CT perfusion imaging parameters in evaluating the biological behavior of gastric carcinoma. Materials and Methods: The perfusion parameters were obtained from patients who experienced the dual source CT scan. And they were divided into several groups according to the extent of cell differentiation of tumor after operation, invasive depths in the gastric wall and whether generating lymph node metastasis. Results: The BF and BV value in the distant metastasis and in the recent distant metastasis as well as the recent distant metastasis group were higher than that of no distant metastasis, meanwhile the evident difference was observed, P＜0.05(F=6.555, 5.972). Besides, the value of Patlak P in the muscularis infiltration group was lower than that in the serosa external group and it had significant difference, P＜0.05(F=5.460). And we concluded that PBV value was negatively correlated to the degree of cell differentiation, besides, positive correlation was observed between BV, BF, Patlak P, PBV value and invasive depths and the extent of distant metastasis. Besides, there were the positive relationship between BV, BF, Patlak P value and distant metastasis. Similarly, Patlak P value was positive related to the degree of lymph node metastasis. Conclusions: The dual source CT perfusion imaging parameters were able to demonstrate biological behaviors of gastric carcinoma. BF and BV value could evaluate distant metastasis and recent distant metastasis after operation or not objectively. Similarly, BV and Patlak P values were able to estimate the depth of the cancer tissue infiltrating the gastric wall objectively.
关键词
胃肿瘤 /
体层摄影术 /
螺旋计算机
Key words
Stomach neoplasms /
Tomography /
spiral computed
李春志;徐荣天;李 响;金银华.
双源CT灌注成像评估胃癌生物学行为的临床研究[J]. 中国临床医学影像杂志. 2009, 20(12): 899-902
LI Chun-zhi;XU Rong-tian;LI Xiang;JIN Yin-hua.
Clinical research of dual source CT perfusion imaging in evaluating biological behavior of gastric carcinoma[J]. Journal of China Clinic Medical Imaging. 2009, 20(12): 899-902
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