酒精依赖患者局部脑血流的初步研究

江旭峰; 于金铃; 张剑戈; 李彪; 朱承谟

中国临床医学影像杂志 ›› 2009, Vol. 20 ›› Issue (2) : 89-90.

论著

酒精依赖患者局部脑血流的初步研究

江旭峰1，于金铃2，张剑戈3，李彪1，朱承谟1

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Study of regional cerebral blood flow in alcohol dependants using statistical parametric mapping

JIANG Xu-feng1, YU Jin-ling2, ZHANG Jian-ge3, LI Biao1, ZHU Cheng-mo1

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摘要

目的：探讨酒精依赖患者局部脑血流的变化。方法：酒精依赖组14例，均为就诊于上海市普陀区精神卫生中心患者，男性，年龄40~54岁，以酒精依赖诊断量表（SCID-AD）确诊存在酒精依赖，所有受检者在前3个月无躯体疾病或其他精神疾病，未服用任何符合精神科药物或停用该类药4周以上。正常对照组20例，男性，年龄38～54岁，无重大躯体疾病，无任何符合诊断标准的精神疾病。常规99Tcm-ECD局部脑血流灌注显像，所有SPECT横断面图像通过专用软件，转换成DICOM格式或analysis 7格式，然后用SPM99进行图像处理和数据分析。结果：SPM显示酒精依赖患者的双侧额叶、右侧扣带回、右侧尾状核局部脑血流明显降低（P<0.05），左侧中及下颞回、左侧丘脑、左侧边缘叶、右侧豆状核的局部脑血流明显升高（P<0.05）。结论：SPM分析显示酒精依赖患者的局部脑血流有明显变化。

Abstract

Objective: To investigate the regional cerebral blood flow(rCBF) alternations in alcohol dependants, and to compare with normal subjects using statistical parametric mapping. Methods: Alcohol dependant group: 14 males, age 40~54 years old, diagnosed with SCID-AD, all of them come from mental health centre of Putuo district Shanghai. All people have neither body nor other mental diseases, and have never used any psychotropic drug or ceased for using such drugs for 4 weeks; control group: 20 males, age 38~54 years old, do not have any body or mental diseases. 99Tcm-ECD SPECT brain imaging were performed, all image transformed to DICOM or analysis 7 format with special program. Then the comparison situation of rCBF was analyzed by SPM. Results: The rCBF of bilateral frontal lobe, right cingulate gyrus, the body of right caudate nucleus were significantly decreased in alcohol dependants, and the rCBF of left inferior temporal gyrus, left middle temporal gyrus, bilateral precentral gyrus, left thalamus, left parahippocampal gyrus, right lentiform nucleus was significantly increased(P<0.05). Conclusion: SPM analysis showed that significant rCBF change in alcohol dependants.

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酒精相关性障碍 / 局部血流 / 放射性核素显像

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江旭峰;于金铃;张剑戈;李彪;朱承谟. 酒精依赖患者局部脑血流的初步研究[J]. 中国临床医学影像杂志. 2009, 20(2): 89-90

JIANG Xu-feng;YU Jin-ling;ZHANG Jian-ge;LI Biao;ZHU Cheng-mo. Study of regional cerebral blood flow in alcohol dependants using statistical parametric mapping[J]. Journal of China Clinic Medical Imaging. 2009, 20(2): 89-90

中图分类号： Ｒ749.62 Ｒ817.4