产后垂体MRI测量与激素水平变化的研究

任伯绪; 黄劲柏; 雷红卫; 陈哲; 张晓方; 杨柳

中国临床医学影像杂志 ›› 2009, Vol. 20 ›› Issue (3) : 156-159.

论著

产后垂体MRI测量与激素水平变化的研究

任伯绪1，黄劲柏1，雷红卫2，陈哲2，张晓方1，杨柳2

作者信息 +

Study on relationship between volume of pituitary gland and changes of hormone levels after delivery

REN Bo-xu1, HUANG Jin-bai1, LEI Hong-wei2, CHEN Zhe2, ZHANG Xiao-fang1, YANG Liu2

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摘要

目的：研究产后垂体形态学变化及其与体内相关激素水平变化的关系。方法：自然分娩的产妇50例，分别于产后7天、3个月、6个月及9个月时行垂体MRI检查及临床生化检查。MRI扫描采用三维破坏性稳态梯度回聚回波（3D-SPGR）序列行垂体3D T1WI扫描。在工作站上手动测量不同时期垂体体积及信号强度。激素生化检查采用免疫放射分析法测定。结果：垂体的平均体积于7天时为（548±44）mm3、3个月时为（526±42）mm3、6个月时为（518±41）mm3、9个月时为（516±41）mm3。垂体前叶与桥脑的相对信号强度在7天与3个月时及3个月与6个月时比较差异有统计学意义，而6个月与9个月间比较差异无统计学意义。临床生化检查：催乳素（PRL）于产后7天水平最高，产后6个月达到非孕期正常范围；促甲状腺激素（TSH）与β-绒毛膜促性腺激素（β-HCG）均于产后7天最高，3个月为正常范围；而雌二醇（E2）在产后7天即在正常范围。结论：产后垂体的体积逐渐减小，前叶信号强度逐渐减低，其形态学变化与相关激素水平的变化具有一定的关联性。

Abstract

Objective: To explore the changes of morphology of pituitary gland and hormone levels after normal delivery. Methods: Fifty volunteers underwent MRI examination and clinical biochemistry analysis on the 7th day, in the 3rd, 6th and 9th month after natural delivery respectively. 3D-SPGR with 3D T1WI sequence was employed in the scanning of pituitary. We measured the volume and signal intensity of gland in each period of time in the image workstation. To determine the hormone levels, the radioimmunoassay method was adopted. Results: The mean volume of the pituitary was (548±44)mm3 on the 7th day, (526±42)mm3 in the 3rd month, (518±41)mm3 in the 6th month, and (516±41)mm3 in the 9th month after delivery. Comparing the signal intensity of anterior lobe of the pituitary with the pon, there were significant differences in their signal contrast between 7 days and 3 months, as well as 3 and 6 months after delivery. There was no significant difference between 6 and 9 months. Serum level of PRL was the highest on the 7th day and decreased to normal after 6 months; levels of TSH and β-HCG reached the highest on the 7th day and returned to normal after 3 months; the level of E2 was normal after 7 days. Conclusion: The volume of pituitary reduces gradually after delivery. Signal intensity of the anterior lobe declines gradually, and there is a certain correlation between the morphologic changes and levels of hormones.

导出引用

任伯绪;黄劲柏;雷红卫;陈哲;张晓方;杨柳. 产后垂体MRI测量与激素水平变化的研究[J]. 中国临床医学影像杂志. 2009, 20(3): 156-159

REN Bo-xu;HUANG Jin-bai;LEI Hong-wei;CHEN Zhe;ZHANG Xiao-fang;YANG Liu. Study on relationship between volume of pituitary gland and changes of hormone levels after delivery[J]. Journal of China Clinic Medical Imaging. 2009, 20(3): 156-159

中图分类号： Ｒ322.54 Ｒ445.2