摘要
目的：探讨兔VX2肝癌经高能聚焦超声（HIFU）治疗后的磁共振灌注加权成像（PWI）的基本成像特点。方法：新西兰大白兔20只，采用组织块种植的方法制成20只兔VX2肝癌模型，使用1.5T MR扫描仪行常规扫描后，采用EPI-SE序列、SENSE技术，于治疗前、后14d对肿瘤行PWI，选取病灶与周围正常肝组织的感兴趣区（ROI），分别测量血流灌注值，进行统计学分析。PWI采用信号强度-时间曲线的最大信号下降斜率（SRSmax）作为定量指标，分析不同ROI的SRSmax变化规律。结果：治疗前、后兔肝VX2瘤中央区及周边区之间的SRSmax的差异有统计学意义（P＜0.05）；瘤旁肝实质之间的SRSmax的差异无统计学意义（P＞0.05）。结论：利用1.5T MR扫描仪进行兔肝VX2瘤灌注成像研究是可行的，PWI可用于评价HIFU治疗后肝脏肿瘤的血管生成、破坏状况；不同ROI的SRSmax变化程度及规律也不同，其PWI表现与肿瘤的坏死程度、范围基本相符。
Abstract
Objective: To discuss the basic characteristic of perfusion-weighted imaging(PWI) in rabbit models of hepatic VX2 tumors after treatment by high intensity focused ultrasound(HIFU). Methods: VX2 tumor in tissue block were implanted into the liver of 20 new Zealand rabbits to make VX2 liver tumor model. After routine scans with 1.5T MR scanner, PWI was performed in 14 days before and after tumor implantation in all animals by using EPI-SE series and SENSE technology. Choose the ROI of rabbit liver VX2 such as central district, marginal area and paratumor parenchyma. Blood flow degrees were measured and analyzed statistically. Maximal signal reduction slope(SRSmax) of the signal intensity versus time curves were created as quantitative variable. Analyze the change of SRSmax in different ROI. Results: There were difference in SRSmax between the central district and the marginal area(P<0.05). No difference in SRSmax in paratumor parenchyma before and after HIFU(P>0.05). Conclusion: It is feasible to study VX2 of rabbit liver perfusion imaging by 1.5T MRI scanner. PWI can be used to evaluate the situation of the liver tumor angiogenesis and angioruin. The findings of VX2 carcinomas on PWI are matched with the levels and scopes of necrosis.
关键词
肝肿瘤 /
模型 /
动物 /
超声检查 /
磁共振成像
Key words
Liver neoplasms /
Models /
animal /
Ultrasonography /
Magnetic resonance imaging
陈 亮;江新青;魏新华;夏建东;吴 梅;吴红珍;郑力强.
高能聚焦超声治疗兔VX2肝癌后磁共振灌注加权成像特征初探[J]. 中国临床医学影像杂志. 2009, 20(3): 174-177
CHEN Liang;JIANG Xin-qing;WEI Xin-hua;XIA Jian-dong;WU Mei;WU Hong-zhen;ZHENG Li-qiang.
Preliminary study of PWI in rabbit models of hepatic VX2 tumors after high intensity focused ultrasound[J]. Journal of China Clinic Medical Imaging. 2009, 20(3): 174-177
中图分类号：
Ｒ735.7
Ｒ445.1
Ｒ445.2
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
