摘要
目的：本研究开展基于QCT数据应用计算机辅助检测系统（CAD）无体模软件对股骨颈骨密度（BMD）测量的研究，对比分析有体模QCT BMD测定方法、DXA方法，旨在能够应用无体模CAD软件开展QCT BMD测量、建立大样本数据库。材料与方法：53例健康志愿者年龄38~70岁，平均57岁。其中男10例，女43例。所有志愿者经胸片、心电图检查及问诊排除有骨质疏松外的其它系统疾病。研究对象均行自第5腰椎至股骨小转子下方（包括双股骨上段）CT扫描（Philips brilliance 64排）。CT扫描时均垫有四标样体模置于体检者骨盆部后方。应用OsteoCAD1.2软件完成无体模竖脊肌组、股内侧肌群组、股外侧肌群组BMD测定，和有体模BMD测定、DXA BMD测定。应用SPSS 10软件分析无体模QCT测定和有体模BMD、DXA BMD测定Linear Regression方法相关分析。结果：无体模竖脊肌组、股内侧肌群组、股外侧肌群组BMD测定结果与有体模BMD测定、DXA BMD测定Linear Regression方法相关分析结果如下：①竖脊肌法测定股骨颈各BMD与有体模、DXA相关性结果：松质骨间的相关系数为0.974，整体骨间的相关系数为0.956，皮质骨间的相关系数为0.904，DXA测量的BMD与两种方法测量的松质骨BMD的相关系数分别为0.906、0.911。②内侧肌群法测定股骨颈各BMD与有体模、DXA相关性结果：松质骨间的相关系数为0.967，整体骨间的相关系数为0.943，皮质骨间的相关系数为0.870，DXA测量的BMD与两种方法测量的松质骨BMD的相关系数分别为0.906、0.868。③外侧肌群法测定股骨颈各BMD与有体模、DXA相关性结果：松质骨间的相关系数为0.976，整体骨间的相关系数为0.955，皮质骨间的相关系数为0.886，DXA测量的BMD与两种方法测量的松质骨BMD的相关系数均为0.906。结论：基于QCT数据应用CAD无体模软件具有与有体模方法和DXA方法相同的测量BMD的能力，其中采用便捷的股内侧肌、股外侧肌作为内部参考具有与竖脊肌相近的结果，能够为医生提供BMD的参考信息，可用于骨质疏松的诊断、健康普查。
Abstract
Objective: To study the values of bone mineral density(BMD) measurement of femoral neck with and without external reference phantom computer-aided detection(CAD) based on QCT data, and DXA, in order to accurately and conveniently study BMD and set up large sample BMD database. Materials and Methods: Volumetric CT scanning(64-slice CT, Philips) of femoral neck were initially performed with external reference phantom(approved by Ethics Committee in our hospital) in 53 health-volunteers(10 men, 43 women, 38~70 years, mean 57 years), scanning ranging from L5 to femoral neck, and then did DXA examination. Doing BMD measurement of femoral neck without external reference phantom with OsteoCAD1.2 software. Medial vastus muscle(MVM) and subcutaneous fat, lateral vastus muscle(LVM) and subcutaneous fat, erector spinae(ES) and subcutaneous fat respectively were determined as internal references. Linear Regression correlation analysis was made by SPSS 10. Results: The correlation of integral, trabecular, cortical BMD measured with and without external reference phantom CAD, DXA were at a high level of significance. The correlation coefficients of integral, cortical, trabecular BMD selected MVM as internal references and that with external reference phantom were 0.956, 0.904, 0.974 respectively. The correlation coefficients of integral, cortical, trabecular BMD selected LVM as internal references and that with external reference phantom were 0.943, 0.870, 0.967 respectively. The correlation coefficients of integral, cortical, trabecular BMD selected ES as internal references and that with external reference phantom were 0.955, 0.886, 0.976 respectively. The correlation coefficients of DXA and trabecular BMD without external reference phantom in MVM, LVM, ES as internal references were 0.911, 0.868, 0.906 respectively. Conclusion: BMD measurement of femoral neck without external reference phantom based on QCT data is an effective and feasible method, both MVM and LVM selected as internal reference is more convenient and has no difference comparing with erector spinae as internal reference.
关键词
股骨颈 /
骨密度 /
体层摄影术 /
X线计算机
Key words
Femur neck /
Bone density /
Tomography /
X-ray computed
潘诗农;赵 衡;赵 凯;廖 伟;康 雁;郭启勇.
基于QCT数据无体模CAD股骨颈BMD测量初步研究[J]. 中国临床医学影像杂志. 2009, 20(3): 178-183
PAN Shi-nong;ZHAO Heng;ZHAO Kai;LIAO Wei;KANG Yan;GUO Qi-yong.
Research on BMD measurement of femoral neck with no-external reference phantom CAD based on QCT data[J]. Journal of China Clinic Medical Imaging. 2009, 20(3): 178-183
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