非小细胞肺癌淋巴结分期的PET/CT准确性评价——Meta分析

张晓颖; 韩冰; 侯跃芳; 吴伟; 周宝森

中国临床医学影像杂志 ›› 2009, Vol. 20 ›› Issue (3) : 184-188.

论著

非小细胞肺癌淋巴结分期的PET/CT准确性评价——Meta分析

张晓颖1，韩冰2，侯跃芳3，吴伟1，周宝森1

作者信息 +

Accuracy of PET/CT on lymph nodes staging in non-small cell lung cancer—a Meta-analysis

ZHANG Xiao-ying1, HAN Bing2, HOU Yue-fang3, WU Wei1, ZHOU Bao-sen1

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文章历史 +

摘要

目的：通过Meta分析来评估PET/CT对非小细胞肺癌（NSCLC）淋巴结分期的诊断价值。方法：检索PubMed数据库和中国生物医学光盘库（1999~2007）的英文和中文文献，按照循证医学诊断试验的评价标准筛选有关PET/CT对NSCLC淋巴结分期诊断的中英文文献。对纳入文献评估后，进行Meta分析，绘制汇总受试者工作特征（SROC）曲线，计算曲线下面积。最后进行敏感性分析。结果：共有13篇中英文文献满足标准纳入研究，权重灵敏度、特异度分别为84％，87％。SROC下面积为90.84％。结论：在综合考虑灵敏度、特异度的情况下，PET/CT对NSCLC淋巴结分期诊断准确性高，临床应用价值较大。

Abstract

Objective: To estimate the diagnostic accuracy of PET/CT for lymph nodes staging in patient with non-small-cell lung cancer using a Meta-analysis with the gold standard of pathological results． Materials and Methods: Search in the studies in English literature in PubMed and Chinese CBM database between 1999 and 2007． Criteria for inclusion and exclusion were according to the criteria of diagnostic research published by Cochrane center． Characteristics of the included studies were evaluated． Subsequently pooled weighted sensitivity, specificity, positive predictive value, negative predictive value were analyzed, and the corresponding 95%CI were calculated． Summary receiver operating characteristic(SROC) curve was performed and the area under the curve(AUC) was calculated． Finally, a sensitivity analysis was performed． Results: Altogether 13 articles that met the standard were included． The pooled weighted sensitivity was 84％ respectively and the pooled weighted specificity was 87％． The area under SROC curve was 90.84％． Conclusion: PET/CT is an accurate noninvasive imaging test for staging of lymph nodes in patient with non-small cell lung cancer, with high sensitivity and specificity．

导出引用

张晓颖;韩冰;侯跃芳;吴伟;周宝森. 非小细胞肺癌淋巴结分期的PET/CT准确性评价——Meta分析[J]. 中国临床医学影像杂志. 2009, 20(3): 184-188

ZHANG Xiao-ying;HAN Bing;HOU Yue-fang;WU Wei;ZHOU Bao-sen. Accuracy of PET/CT on lymph nodes staging in non-small cell lung cancer—a Meta-analysis[J]. Journal of China Clinic Medical Imaging. 2009, 20(3): 184-188

中图分类号： Ｒ734.2 Ｒ814.42 Ｒ817.4