多中心临床研究：采用X线衰减校正提高99mTc-3PRGD2肺癌SPECT图像定量分析精确性

杨爱民; 石希敏; 戴皓洁; 辛军; 赵新民; 王喆; 郑山; 高蕊; 李眉; 缪蔚冰; 赵周社; 贾兵; 朱朝晖; 汪静; 吴文凯

中国临床医学影像杂志 ›› 2013, Vol. 24 ›› Issue (5) : 321-324.

论著

多中心临床研究：采用X线衰减校正提高99mTc-3PRGD2肺癌SPECT图像定量分析精确性

杨爱民1，石希敏2，戴皓洁3，辛军4，赵新民5，王喆6，郑山7，高蕊1，李眉3，
缪蔚冰7，赵周社8，贾兵9，朱朝晖2，汪静5，吴文凯10，李方2

作者信息 +

Multicenter clinical study: the use of X-ray attenuation correction to improve quantitativeanalysis precision for 99mTc-3PRGD2 lung cancer SPECT image

YANG Ai-min1, SHI Xi-min2, DAI Hao-jie3, XIN Jun4, ZHAO Xin-min5, WANG Zhe6, ZHENG Shan7, GAO Rui1, LI Mei3, MIAO Wei-bing7, ZHAO Zhou-she8, JIA Bing9, ZHU Zhao-hui2, WANG Jing5, WU Wen-kai10, LI Fang2

Author information +

文章历史 +

摘要

目的：采用X线衰减校正提高前瞻性、多中心研究中99mTc-3PRGD2肺癌SPECT图像定量分析的精确性。方法：经病理确诊的肺癌患者27例，其中肺腺癌23例、鳞癌4例。患者静脉注射99mTc-3PRGD2后40分钟顺序进行全身和局部断层扫描。采用迭代图像重建方法, 对获得的99mTc-3PRGD2 SPECT图像进行X线衰减校正（CTAC）和非衰减校正重建（NAC）。测量CTAC和NAC病灶所在层面的总计数，感兴趣区域（ROI）病灶的总计数、最大计数和平均计数。分别以病灶ROI内最大计数的38%、42%和48%作为阈值测量CTAC和NAC图像病灶最大长径。结果：经过CTAC后病灶所在层面总计数增加2.09倍，ROI区域病灶的总计数增加3.32倍，病灶最大计数和平均计数与本底比值分别提高了65.9%和70.3%。以病灶ROI最大计数42%作为阈值，CTAC后的病灶最大长径为（5.65±2.77） cm,与CT测量结果一致。结论：采用X线衰减校正是提高99mTc-3PRGD2定量分析的有效方法。

Abstract

Objective: Using X-ray attenuation correction to improve a prospective, multicenter study of 99mTc-3PRGD2 SPECT image quantitative analysis precise in lung patients. Methods: 27 patients, adenocarcinoma of 23 cases and squamous cell carcinoma of 4 cases, diagnosed by pathology. Images of whole body scan and local tomography were obtained after 99mTc-3PRGD2 injection of 40 minutes intravenously. Iterative image reconstruction method was used to obtain the X-ray attenuation correction(CTAC) and no attenuation correction reconstruction(NAC) on the basis of 99mTc-3PRGD2 SPECT images. Total count of the lesions slice, total count, maximum and average count of the region of interest(ROI) were extracted individually from the slices of CTAC and NAC frames. The maximum count 38%, 42% and 48% within ROI were chosed as the threshold to measure the diameter length of CTAC and NAC image focus. Results: The results showed that after CTAC, the total count, of the focus slice was increased 2.09 times, the total count of the ROI was increased 3.32 times, maximum and mean counts and the background ratio were increased by 65.9% and 70.3%, individually. With the maximum count 42% of the lesion ROI as the threshold, the lesions maximum size was of (5.65±2.77) cm after CTAC, which is coincidence with CT measurement results. Conclusion: Using X-ray attenuation correction helps to improve 99mTc-3PRGD2 quantitative analysis.

导出引用

杨爱民;石希敏;戴皓洁;辛军;赵新民;王喆;郑山;高蕊;李眉;缪蔚冰;赵周社;贾兵;朱朝晖;汪静;吴文凯0;李方. 多中心临床研究：采用X线衰减校正提高99mTc-3PRGD2肺癌SPECT图像定量分析精确性[J]. 中国临床医学影像杂志. 2013, 24(5): 321-324

YANG Ai-min;SHI Xi-min;DAI Hao-jie;XIN Jun;ZHAO Xin-min;WANG Zhe;ZHENG Shan;GAO Rui;LI Mei;MIAO Wei-bing;ZHAO Zhou-she;JIA Bing;ZHU Zhao-hui;WANG Jing;WU Wen-kai0;LI Fang. Multicenter clinical study: the use of X-ray attenuation correction to improve quantitativeanalysis precision for 99mTc-3PRGD2 lung cancer SPECT image[J]. Journal of China Clinic Medical Imaging. 2013, 24(5): 321-324

中图分类号： Ｒ734.2 Ｒ817.4