双指数扩散加权成像参数与鼻咽癌临床分期的关系

李飞平; 卢强; 胡英; 文露; 于小平

中国临床医学影像杂志 ›› 2015, Vol. 26 ›› Issue (4) : 234-237.

论著

双指数扩散加权成像参数与鼻咽癌临床分期的关系

李飞平，卢强，胡英，文露，于小平

作者信息 +

Relationship between parameters of biexponential diffusion weighted imaging and nasopharyngeal carcinoma clinical stage

LI Fei-ping, LU Qiang, HU Ying, WEN Lu, YU Xiao-ping

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文章历史 +

摘要

目的：探讨双指数模型（IVIM）扩散加权成像参数与鼻咽癌（NPC）临床分期的相关性，评价其在评估NPC侵袭和转移方面的价值。方法：对49例NPC初治患者行IVIM扩散加权成像和临床分期（中国2008分期），分析IVIM各参数（ADCstand、ADCslow、ADCfast、Ffast）与临床分期之间的相关性。结果：T分期与ADCslow值呈负相关（r=-0.356，P=0.012），与ADCfast值呈正相关（r=0.388，P=0.006）；ADCstand值与总分期（r=0.410，P=0.003）、N分期（r=0.313，P=0.029）、M分期（r=0.349，P=0.014）均呈正相关；ADCstand值在不同总分期、N分期及M分期之间存在显著差异（P<0.05）；ADCslow值在不同总分期、T分期及N分期之间亦存在显著差异（P<0.05）。结论：NPC的总分期、T分期、N分期和M分期与多个IVIM参数之间存在相关性。IVIM参数有可能作为无创性反映NPC组织特性、侵袭性及疾病进展程度的影像学生物标志，为临床治疗方案的设计提供参考依据。

Abstract

Objective: To explore the correlations between biexponential model(IVIM) of diffusion-weighted imaging parameters and nasopharyngeal carcinoma(NPC) clinical stage, and to evaluate its value in assessing invasion and metastasis of NPC. Methods: Forty-nine newly diagnosed NPC patients received MRI examination and clinical staging was decided based on Chinese 2008 staging system. The correlations between IVIM parameters(ADCstand, ADCslow, ADCfast, Ffast) and clinical stage were analyzed. Results: T stage showed negative correlation with ADCslow(r=-0.356, P=0.012) and positive correlation with ADCfast(r=0.388, P=0.006). ADCstand showed a positive correlation with overall stage(r=0.410, P=0.003), N stage(r=0.313, P=0.029) and M stage(r=0.349, P=0.014). ADCstand showed significant differences in different overall stages, N stages and M stages(P<0.05), and ADCslow showed significant differences in the different overall stages, T stages and N stages(P<0.05). Conclusion: IVIM parameters of primary NPC lesions have significant correlations with clinical stages. IVIM parameters may act as imaging biomarkers for non-invasive assessing of the tumour microstructure, disease level and aggressiveness of NPC.

导出引用

李飞平;卢强;胡英;文露;于小平. 双指数扩散加权成像参数与鼻咽癌临床分期的关系[J]. 中国临床医学影像杂志. 2015, 26(4): 234-237

LI Fei-ping;LU Qiang;HU Ying;WEN Lu;YU Xiao-ping. Relationship between parameters of biexponential diffusion weighted imaging and nasopharyngeal carcinoma clinical stage[J]. Journal of China Clinic Medical Imaging. 2015, 26(4): 234-237

中图分类号： Ｒ739.63 Ｒ445.2