摘要
目的：研究CD31、CD34在结节性甲状腺肿和甲状腺腺瘤的表达情况，为超声造影鉴别结节性甲状腺肿和甲状腺腺瘤提供病理依据。方法：回顾性观察30例结节性甲状腺肿和30例甲状腺腺瘤患者的超声造影过程，并用TomTec软件绘制时间-强度曲线获得定量参数。对术后石蜡标本行免疫组化染色，进行微血管密度测定，并与超声造影定量参数进行相关性分析。结果：30例结节性甲状腺肿中23例表现为与周围甲状腺实质等增强，4例表现为高增强，3例表现为低增强。30例甲状腺腺瘤中29例表现为高增强，1例表现为等增强。时间-强度曲线显示定量参数mTT、IMAX两组之间比较，差异具有统计学意义，RT、TTP无统计学差异。免疫组化染色显示甲状腺腺瘤的微血管较丰富，超声造影定量参数RT、TTP、mTT与微血管密度呈负相关，IMAX与微血管密度呈正相关。结论：结节性甲状腺肿和甲状腺腺瘤的超声造影增强特征不同，有助于二者的诊断和鉴别诊断。
Abstract
Objective: To study the expression of CD31 and CD34 in nodular goiter and thyroid adenoma, and to provide the pathologic bases for differentiating nodular goiter from thyroid adenoma with contrast-enhanced ultrasound. Methods: CEUS process of 30 cases of nodular goiter and 30 cases of thyroid adenoma was retrospectively analyzed, and the time-intensity curve was analyzed by TomTec software. Immunohistochemical staining was performed to evaluate the MVD in surgical specimens. Quantitative parameters and MVD were assessed by the Spearman’s Rank correlation analysis. Results: After enhancement, 23 cases of nodular goiter showed isoechoic, 4 cases of nodular goiter showed hyperechoic, 3 cases of nodular goiter showed hypotonic, 29 cases of thyroid adenoma showed hyperechoic, and 1 case of thyroid adenoma showed isoechoic. There was significant difference in mTT and IMAX. RT and TTP were not statistically significant. Thyroid adenoma had rich microvessels. RT, TTP and mTT showed negative correlations while IMAX showed positive correlation with MVD. Conclusions: CEUS enhancement patterns are different between nodular goiter and thyroid adenoma, and it helps the diagnosis and differential diagnosis.
关键词
甲状腺肿 /
结节性 /
甲状腺肿瘤 /
超声检查
Key words
Goiter /
nodular /
Thyroid neoplasms /
Ultrasonography
张红丽;姜 珏;周 琦;李 苗;雷小莹.
CD31、CD34在结节性甲状腺肿和甲状腺腺瘤的表达及其与超声造影的相关性[J]. 中国临床医学影像杂志. 2015, 26(4): 243-246
ZHANG Hong-li;JIANG Jue;ZHOU Qi;LI Miao;LEI Xiao-ying.
The expression of CD31, CD34 in nodular goiter and thyroid adenoma and the correlation with contrast-enhanced ultrasound[J]. Journal of China Clinic Medical Imaging. 2015, 26(4): 243-246
中图分类号：
Ｒ581.3
Ｒ736.1
Ｒ445.1
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